fits a large literature where lower chronic inflammation aligns with better outcomes in aging. However, CRP was not available for everyone, so we cannot lean too hard on that result here. Basically, markers tied to inflammatory processes seem calmer in those who eventually reach 100.
Cholesterol and Iron
Cholesterol often sparks debate. Low total cholesterol sat with a reduced likelihood of becoming a centenarian in this cohort. High total cholesterol did not raise or lower the odds of reaching 100. That does not mean high cholesterol is safe for your heart. It means this longevity analysis, using odds across quintiles, did not find a simple linear benefit from pushing total cholesterol downward. Context is everything. Heart disease prevention focuses on LDL cholesterol, not total cholesterol alone. National guidance still targets healthy LDL levels, because LDL drives plaque formation. The CDC lists an optimal LDL near 100 mg/dL for most
